Biohazardous agents are infectious microorganisms or their toxins, that when transmitted, causes or may cause diseases in humans. Biosafety guidelines in Medical Laboratories describe the fundamental requirements for safe handling and containment of infectious microorganisms and all hazardous biological materials. The basic principles of containment include best microbiological practices, use of safety equipment and facility gadgets that protect the laboratory staff, the environment and the community from exposure to infectious agents that are handled or stored in the laboratory. The Laboratory staff should have the knowledge of the location and hazards of the infectious agents used in the laboratory for the sake of emergency responses planning purposes. Risk assessment is the process that involves the appropriate selection of microbiological practices,, safety equipment and facility safety protectors that can prevent laboratory associated (acquired) infections